Inhibition of Coxsackievirus A24 in permissive Hep2 cells by small interfering RNA (siRNA)
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چکیده
منابع مشابه
A small interfering RNA targeting coxsackievirus B3 protects permissive HeLa cells from viral challenge.
We examined the ability of small interfering RNAs (siRNAs) to disrupt infection by coxsackievirus B3 (CVB3). The incorporation of siRNAs dramatically decreased cell death in permissive HeLa cells in parallel with a reduction in viral replication. Three of four siRNAs had potent anti-CVB3 activity. The present study thus demonstrates that the antiviral effect is due to the downregulation of vira...
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Gene silencing using RNAi (RNA interference), has recently been used as a successful laboratory technique in determining the function and control of gene expression and provides a wide range of applications in molecular biology and gene therapy. RNAi is a method of suppressing gene expression. In this direction, a single-stranded RNA molecule of about 21–23 nucleotides, called siRNA (small inte...
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ژورنال
عنوان ژورنال: IOSR Journal of Pharmacy and Biological Sciences
سال: 2017
ISSN: 2319-7676,2278-3008
DOI: 10.9790/3008-1203042126